Researcher profile #6631
Ageing as a Two-Phase Process: Development of a new Theoretical Framework Flaminia Zane (1) , Claire Macmurray (1) , Clémence Guillermain (2) , Céline Cansell (3) , Nicolas Todd (4) , Michael Rera (5) Frontiers in Aging (2024) https://hal.science/hal-04423745/
A scenario for an evolutionary selection of ageing T. Roget, C. MacMurray, P. Jolivet, S. Méléard, M. Rera eLife (2024) https://elifesciences.org/reviewed-preprints/92914
Smurfness-based two-phase model of ageing helps deconvolve the ageing transcriptional signature Flaminia Zane, Hayet Bouzid, Sofia Sosa Marmol, Mira Brazane, Savandara Besse, Julia Lisa olina, Céline Cansell, Fanny Aprahamian, Sylvère Durand, Jessica Ayache, Christophe Antoniewski, Nicolas dd, Clément Carré, Michael Rera Aging Cell (2023) https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13946
Two phases model of ageing in mice: towards a better identification of age-related and late-life metabolic decline [Registered Report Stage 1 Protocol] Céline Cansell (1) , Vivien Goepp (2, 3, 4, 5) , Fanny Bain , Nicolas Todd (6) , Veronique Douard (7) , Magali Monnoye (7) , Clara Sanchez (8) , Nicolas Pietrancosta (9, 10) , Carole Rovere (8) , Raphael Gp Denis (11) , Serge Luquet (11) , Michael Rera (12) BMC Biology pre-registered protocols (2023) https://hal.science/hal-04234744/
Ethical and social implications of approaching death prediction in humans - when the biology of ageing meets existential issues Marie Gaille, Marco Araneda, Clément Dubost, Clémence Guillermain, Sarah Kaakai, Elise Ricadat, Nicolas Todd, Michael Rera BMC Medical Ethics (2020) https://bmcmedethics.biomedcentral.com/articles/10.1186/s12910-020-00502-5
The Smurf transition: new insights on ageing from end-of-life studies in animal models Rera, Michael ; Vallot, Céline; Lefrançois, Christel Current Opinion in Oncology (2018) https://univ-rochelle.hal.science/hal-01981182/file/Reraopinion2017.pdf
Two phases of aging separated by the Smurf transition as a public path to death E. Dambroise, L. Monnier, L. Ruisheng, H. Aguilaniu, J.-S. Joly, H. Tricoire, M. Rera Scientific Reports (2016) https://www.nature.com/articles/srep23523
A New, Discontinuous 2 Phases of Aging Model: Lessons from Drosophila melanogaster Hervé Tricoire, Michael Rera PLOS ONE (2015) https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141920
Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila Michael Rera, Rebecca I. Clark, and David W. Walker PNAS (2012) https://www.pnas.org/doi/abs/10.1073/pnas.1215849110
I've been working for 10 years now to build a new theoretical framework for the study of aging. Based on a discovery I made in the Drosophila fly, this new theoretical framework proposes to consider aging not as a progressive and continuous process but as consisting of two consecutive and necessary phases. The transition between these two phases is detected in vivo by increased intestinal permeability to a small food dye.
In recent years, my research team and I have shown that this theoretical framework is applicable to other model organisms (nematode, zebrafish, mouse). The experimental approaches enabled by this framework allow us to identify molecular and physiological characteristics of individuals in the second phase of their lives, and to test the effect of interventions affecting healthy life expectancy on both phases in order to better understand what mechanisms lead to aging and associated declines.