Researcher profile #6612
Prieur-Drevon D, Pabst L, Mascaux C, Sauleau EA, Chevalier C, Ruppert E., Calvel L. Sleep quality in lung cancer and specifically non-small-cell lung cancer: a rapid review. Support Care Cancer [Internet]. 1 févr 2025 [cité 30 janv 2025];33(2):1 39
Jeffrey Hubbard, Mio Kobayashi Frisk, Elisabeth Ruppert, Jessica W. Tsai, Fanny Fuchs, Ludivine Robin-Choteau, Jana Husse, Laurent Calvel, Gregor Eichele, Paul Franken, and Patrice Bourgin. Dissecting and modeling photic and melanopsin effects to predict sleep disturbances induced by irregular light exposure in mice. Proc Natl Acad Sci U S A. 22 juin 2021;118(25):e2017364118.
Comtet H, Geoffroy PA, Kobayashi Frisk M, Hubbard J, Robin-Choteau L, Calvel L, et al. Light therapy with boxes or glasses to counteract effects of acute sleep deprivation. Sci Rep. 2 déc 2019;9(1):18073.
Vercueil C, Sauleau E, Calvel L. [End-of-life care pathways of patients followed in palliative care in Strasbourg: A retrospective study]. Bull Cancer. nov 2022;109(11):1193‑201.
Prieur-Drevon D, Abel M, Laplace J, Gardelle B, Calvel L, Lamouille-Chevalier C. Confirming and notifying death: blended learning acceptability among medical students, a pilot mixed-methods study. Medical Education Online. 9 mars 2026;31(1):2641306
Chaumier F, Angoulvant D, Gyan E, Calvel L. Heterogeneity of professional goals among residents enrolled in a palliative care track: results of a national online survey in France. Med Educ Online. déc 2025;30(1):2520380.
Calvel L, Blondet LV, Chedotal I, Grosshans D, Lefebvre F, Mounier G, et al. Difficulties in providing palliative care in identified palliative care beds: An exploratory survey. Presse Med. août 2019; 48 (7-8 Pt 1):e209 15.
Influences of sleep on quality of life in palliative care
Sleep disorders, whose prevalence reaches 9 to 69% in palliative situations, paradoxically remain under-identified and under-managed, despite being a central regulator of quality of life, mood and resilience in the patient. My research articulates basic neuroscience and clinical palliative medicine and is organized into four complementary axes.
Identifying and characterizing - Phenotypic epidemiology of sleep disorders in specialized facilities, based on a prospective study in advanced thoracic oncology and towards a multicenter protocol.
Understanding - Exploration of neurobiological and neurophysiological mechanisms at the interface of sleep, pain and mood, rooted in fundamental work on melanopsinergic phototransduction (Sleep 2015; PNAS 2021).
Intervene and evaluate - Six multimodal, complementary and progressive therapeutic lines of action: passive virtual reality (randomized controlled trial, CPP validated), co-designed interactive virtual reality (Franco-Hungarian program), intelligent conversational accompaniment of nocturnal discomfort (Fondation des Gueules Cassées / FHU DATA-SURGE), ambient light therapy enriched with turquoise blue (translational outcome of preclinical program), aromatherapy by dry inhalation, and pharmacological rationalization of nocturnal prescriptions.
Transmitting and transforming - Training professionals, participatory research with patients and their loved ones, and interdisciplinary doctoral supervision at the intersection of ethics, social sciences and neuroscience.